Saturday, March 5, 2011

Assignment #2: Due Friday, March 18


For your second assignment, worth 10 points, you need to find and summarize articles describing your protein from the biochemical literature. Find information that tells us something interesting about your protein. What does it do? Does it catalyze a reaction? If so, write out the reaction (you don't need to show structures yet). What does it do for a cell or the organism? Are there diseases associated with it? If you're looking for examples, check out some of those posted in the Virtual Protein Museum, the Protein Data Bank Molecule of the Month site, or the Protein Structure Initiative Featured Molecules page.

You must find a minimum of 3 articles, at least one of which must be a primary research article (you may use review articles for the others). Then you should write a one paragraph summary of the most interesting items from the article--remember, your goal is to convince your friends and family of the beauty or amazingness of your protein. Include a link to the article in your blog post.

Where should you look?

  • The Protein Data Bank page for your protein will have a link to the article linked to the structure.
  • Another good place to look is the PubMed site. You can look for review articles here, too (these will be a great source of the interesting features of your protein); you can then look for a primary article from the references listed in the review. To look for reviews, select the [Limits] tab and then scroll until you find the [Reviews] tab. For further instructions on PubMed, click here.
  • Highwire is another great source for articles. Once you find an article, you can also get a list of other articles that have cited it. This may also help you find reviews.
You need not read the whole article--take a look at the abstract and the introduction (which will have more citations) to see what the authors found about your protein.

If you have selected a protein featured at either the Protein Data Bank Molecule of the Month page or the Protein Structure Initiative Featured Molecules page, you must also cite the source on your blog page.

Post here when you have finished.

30 comments:

  1. http://ael22.blogspot.com/2011/03/article-summaries-on-amazing-dicer.html

    Amanda Links

    ReplyDelete
  2. http://awesomepossumprotein.blogspot.com/2011/03/summary-of-my-amazing-awesome-possum.html

    Chelsey Knapper

    ReplyDelete
  3. http://laproteinadealex.blogspot.com/2011/03/what-this-thing-does.html

    ReplyDelete
  4. http://jadproteinofyear2011.blogspot.com/

    Adam Driscoll

    ReplyDelete
  5. http://laurensproteinoftheyear.blogspot.com/2011/03/assignment-2.html

    Lauren Bylsma

    ReplyDelete
  6. http://mhc-allison.blogspot.com/

    ReplyDelete
  7. http://dystrophin-tylerveldkamp.blogspot.com/

    ReplyDelete
  8. http://ejd28.blogspot.com/2011/03/little-bit-more-about-mscs.html

    ReplyDelete
  9. http://mmh24phosphofructokinase1.blogspot.com/2011/03/interesting-research-regarding.html

    ReplyDelete
  10. http://trprs.blogspot.com/2011/03/assignment-2_17.html

    ReplyDelete
  11. http://divalenttransporter.blogspot.com/2011/03/publications-regarding-this-specific.html

    ReplyDelete
  12. http://lnicole3.blogspot.com/2011/03/secret-of-life.html

    ReplyDelete
  13. http://nitrogenaseprotein.blogspot.com/2011/03/nitrogenase-not-just-another-bosch-up.html

    ReplyDelete
  14. http://proteinoftheyear.blogspot.com/2011/03/assignment-2-few-articles-teach-us.html

    ReplyDelete
  15. http://malatesynthase.blogspot.com/2011/03/in-news.html

    ReplyDelete
  16. http://alysonanneyva.blogspot.com/2011/03/vibrio-chloerae.html

    ReplyDelete
  17. Done with assignment 2

    http://bjburkhart.blogspot.com/

    ReplyDelete
  18. http://amerwood261.blogspot.com/

    Amanda Erwood

    ReplyDelete
  19. http://keithvandusen.blogspot.com/

    ReplyDelete
  20. Assignment 2 complete

    http://proteinseaons.blogspot.com/

    ReplyDelete
  21. http://griffithbiochem.blogspot.com/2011/03/lysozyme-characteristics.html

    ReplyDelete
  22. http://fibrinforme.blogspot.com/2011/03/fibrin-article-summaries.html?showComment=1301282304823#c3359759505657081629

    ReplyDelete
  23. http://beta-3alcoholdehydrogenase.blogspot.com/2011/03/interesting-functions-of-alcohol.html?showComment=1301365532062#c734460632585528972

    ReplyDelete
  24. http://glutaminesynthetase.blogspot.com/2011/03/summaries-of-glutamine-synthetase.html

    ReplyDelete
  25. http://christinetimmer.blogspot.com/2011/03/assignment-2-nitric-oxide-synthase-in.html

    ReplyDelete
  26. http://dnaligase.blogspot.com/2011/03/dna-ligase-literature-information.html

    ReplyDelete
  27. http://bacteriorhodopsin.blogspot.com/

    ReplyDelete
  28. http://dipeptidylpeptidase.blogspot.com/2011/04/deipeptidyl-peptidase-information.html

    ReplyDelete
  29. The anti-freeze protein snow flea quaziracemate has a simple but unique structure. It is an 81 reside protein that is dominantly glycine rich. Its sections, numerically labeled 1-6 are split evenly by function. That is, the odd numbered sections are hydrophobic sections, which function as the ice crystal-binding site. This surprised me because I would’ve naturally assumed that the hydrophilic site would bind the ice crystals. The ice binding site is alanine rich and is structured just so, so that the ice crystal fits in place. Also, experiments have shown that the protein’s backbone structure is compromised at 25 degrees C and has trouble because of hydrogen bonding that occurs. This effect is also shown to be irreversible when the temperature is lowered again. The question is how does this species of flea keep the protein in its folded structure?

    1)
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719301/pdf/nihms122408.pdf
    2)
    file:///Users/mowgli/Downloads/Structural%20Basis%20for%20superior%20activity%20of%20large%20isoform%20of%20snow%20flea%20antifreeze%20protein.html
    3)
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1796811/pdf/1717.pdf

    ReplyDelete